Rose is surprisingly and vehemently opposed to Bernard's plan to create an S.O.S. signal; romantic sparks are rekindled between Jack and Kate when they trek into the jungle to propose a "trade" with "The Others"; and Locke begins to question his faith in the island.
With Kyle left behind, Cartman makes his way to FOX to get the Family Guy episode pulled, hoping to ultimately get rid of the show once and for all.
A man dressed in a superhero costume is found dead in an alley, after saving a man being mugged. Mac, Stella, and Dr. Hawkes find his clothes in a nearby phone booth. Danny and Lindsay investigate the murder of an NFL first-round draft pick, known as "Superman."
J.D.'s brother Dan returns for a surprise visit and Elliot learns that J.D. has been telling Dan that she still likes him. A patient with weight-related problems needs an MRI, but he's too big for the machine. Carla and Turk freak out when they begin to discuss baby names. Meanwhile, Dr. Kelso assigns Dr. Cox to assist Ted with malpractice claim paperwork after Dr. Cox insults Dr. Kelso's son.
Veronica begins having dreams involving the dead students from the bus crash, who drop clues along the way. Meanwhile, Logan and Wallace become unlikely lab partners in Mr. Wu's class, and Keith helps Clemmons expose a doctor's scam.
Unhappy because Rory hasn't really forgiven him, Logan takes off with his friends. Rory runs into Luke and April at a bookstore in Philadelphia.
When a six-year-old boy is brought in with the same symptoms as another patient who died years ago under House's care, House believes the cases are identical and he can predict the course of the boy's illness. Meanwhile, the clinic hosts a poker night to benefit the oncology department.
The Unit must try to get a listening device to an agent inside the Iranian embassy where U.S., Iranian, and Russian diplomats are meeting. Many are speculating that the Russians are attempting to sell the Iranians material to make a nuclear weapon. Meanwhile at the base, Tom tries to end his affair with Tiffy but she won't listen to him and Kim notices Tiffy at a motel room and does not know what she should do.
Moz is a drug dealer and has very strange clientele who come and go from his flat.
Doug's lie to get Carrie to let him ride a rollercoaster at an amusement park blows up in his face. Meanwhile, Arthur lets Deacon shuttle him around in a wheelchair so they can jump to the front of the park's lines and Danny and Spence search for girls to pick up.
Phil Hellmuth isn't going to be pushed around and Daniel Negreanu isn't leaving until he's even. "The Poker Brat" and "Kid Poker" join Antonio Esfandiari, Jennifer Harman, Todd Brunson, Johnny Chan, Barry Greenstein, and Jerry Buss for the High Stakes Poker Season 1 finale.
The remaining candidates launch a new pizza sandwich for 7-Eleven.
The eleven remaining candidates are assigned to create activity areas to benefit a children's charity in a renovation-themed task.
Kris must decide between staying at Raintree or traveling to Europe to further her career; Baby Wildfire must be sold.
The Camdens receive official invitations to Simon and Rose's wedding, and to their dismay, they learn that the date conflicts with Matt and Sarah's graduation from medical school. As this news creates a tailspin with the family, Rose stubbornly refuses to change the wedding date. Eric and Kevin think they have a solution to the problem, but when Annie disapproves of their methods, she looks for help from an entirely different source. Meanwhile, Ruthie wants to enroll in a summer program that takes place in Scotland.
The CSI team must try to find out who is trying to kill a young couple who are released from prison. The couple was made out to be “media darlings” and soon find that not everyone though of them as darlings. Calleigh must work with her ex-boyfriend to help solve the case.
Jack and Wayne locate a recording that definitively proves Logan's involvement in the terrorist conspiracy, but Henderson corners them in the hopes of destroying the incriminating tape. Logan tries to cover his tracks by issuing a warrant for Jack's arrest. Audrey contacts her father for help, while Chloe gives her cover while helping Jack evade CTU.