Homer is stoked for a party, where Lenny shows off his new plasma screen HD TV. Three days later and Homer still hasn’t left Lenny’s apartment. Lenny eventually gets him to leave and Marge enters them in a contest where they can win a plasma TV of their own. They don’t win, but 3rd place gets them a tour of the FOX studios, where Homer learns about a wife-swapping show where he can win enough money to buy his own plasma TV. Marge agrees to appear and they exchange wives with the Heathbar family. Charles Heathbar winds up falling in love with Marge (who is giving him what he needs), while his real wife Verity finds Homer detestable.
Hal's friend Trey tells him to come to his dental office when he looses a tooth during a poker game, but their friendship becomes in jeopardy when Hal's faced with a $2,000 bill and causes a fight between them. Reese, meanwhile, teaches Lois how to ride a bike, while Malcolm and Dewey find sleeping as their new favorite pastime.
In order to help a mother and her unborn child, David starts a research to fight a very strong strain of the HIV virus which she has and for which there is no known cure.
While the gang begins to turn on itself, Tony finds himself at the threshold.
Although often overlooked, caves are remarkable habitats with bizarre wildlife. Explore the structures created inside the earth as well as the adaptations animals have made to thrive in these environments.
Peter gets a vasectomy and loses all his sex drive. Lois begins to gain weight, and as a result, Peter's regains his interest in his wife. When Lois' habits get out of control, she has a heart attack. The surgeon must remove Lois' fat to reach her heart, returning her to her normal weight. Meanwhile, Stewie's half-brother Bertram returns to confront him, where they have a war for control over the playground.
Vilgax tries to get the Omnitrix for himself while Grandpa Max's strange past becomes known, causing a showdown between Vilgax and the Tennyson family.
With the outbreak-mutant situation the Turtles feel they have to deal with and Donatello sick his brothers leave him with Casey and April for care. But Donatello is not sick but in the last stages of a second mutation.
April Fools Day: Ned, Cookie, and Gordy team up to fool the king of April Fooling: Vice Principal Crubbs. Moze tries to break up with Seth, but he thinks it's a prank. Excuses: When a dog actually eats Ned's homework, nobody believes his excuse.
Lilly is ecstatic when she gets two tickets to a Hannah Montana concert and invites Miley to accompany her. Miley refuses, saying that she doesn't like Hannah Montana. Miley's dad, Robby, tries to convince her to tell Lilly her secret: That she is Hannah Montana. When Lilly finds out what Miley's been hiding, will she treat her the same? Jackson won't take no for an answer when he wants to borrow money for his big date. But his dad keeps refusing to be his personal ATM.
When no one watches Keely's investigative reports show Pim comes to the resuce by offering to help make her popular amongst her viewers again but Keely realizes that Pim is just abusing her to make money and goes back to making "real news" with Phil.
A labeling mix-up between animal musk and after shave causes Harold a lot of grief when he goes to meet his fiance's family. Red gives up on parallel parking and tries his hand at perpendicular parking. Bill helps Red clear the trees that have grown around an abandoned boat. Mike tries to guess the word 'parent' in the Word Game. Red converts an electric blanket into a table warmer and makes a spill-proof submarine sandwich.
Fellow con-man James Whittaker Wright III enlists the help of the Hustle crew to avenge his legendary grifter grandfather's treatment by Cornfoots Merchant Bank. Posing as enterpreneurs and investors they try to get back at the bank by a massive con. But have the Hustle crew forgotten just how devious James Whittaker Wright III can be?
Maddie is having her Sweet 16, and likes to have her party at the Tipton. On that same day, London decides to throw her own bash. Zack ends up trying to figure out what to get Maddie for her special day.
After preventing a goblin from aquiring a magic stone, Ah-Mah narrates the story to June how Ray Ray earned the ability to see the magic before she retired. Also, in the flashback, three demons plot to use the Staff of Elusidation to find out which one of Ah-Mah's grandkids has the magic ability of the Te Xuan Ze and drain it from him. Monroe must watch over and protect the children while Ah-Mah fights some Fire Demons. What will happen then?
In the series finale, Valerie finally has her dream wedding to Vic, but there are a few problems. Val, Holly, and Lauren are stuck at a spa where an escaped convict is being searched for, making the three of them late for the wedding.
Raven must deal with entertaining both her boyfriend and her boss, Donna Cabonna, on the same night.
Everyone becomes obsessed with card collection when Coco lays magical eggs filled with cards.
A girl who is unable to walk or talk becomes a human portal for a demon.
Vlad is back, only now he's afflicted with a serious case of ecto-acne, a direct result of the college lab accident with Jack and Maddie. To ensure Danny helps him find a cure, Vlad infects Sam and Tucker with his disease, and Danny turns to Clockwork for help. Danny convinces Clockwork to let him go back in time to make sure the accident that injures Vlad never happens. Unfortunately, when he changes the past, he changes the present. When he arrives back in the present day, Maddie is married to Vlad and living in Wisconsin, and Jack's a ghost named Jack Plasmius! Now, Danny must go back in time for a second time to ensure his parents get together, but when he does, will that mean ecto-acne doom for Tucker and Sam?