A man's gunshot-induced amnesia causes Jones and Medavoy to concoct an unconventional way to nail his assailant. Meanwhile, a man Sipowicz put away twenty years ago for raping and murdering a 12-year-old girl goes free after DNA testing exonerates him, and Ortiz and Ronson bust a gruesome underground network pre-teen prostitution ring.
Stuck at home in recovery, Ozzy grows restless and cranky. He misses Sharon, hates the bulky neck brace, and laments the extra pounds he’s packing on without his workouts.
Jack reluctantly works with Kim on an undercover job that may help them gain an advantage over Saunders. Palmer informs his cabinet of the crisis, while Saunders makes yet another demand. Chase tracks down the man who left the hotel and learns that the virus is spreading to the general public.
Nick 's future at the firm is in question because of because of a lawyer Burton thinks quite highly of but he doesn't feel she is ready to be a partner in the firm just yet. Sandra however blames Nick for not being voted into the firm. Sandra files a sexual discrimination lawsuit against Nick and his firm causing Jake to hold an executive meeting to consider what action to take against Nick. Burton is worried about his son 's future at the firm.
Jason and Richard are sued. Rory is upset by a decision Dean has made. Dean is told to stop spending time with Rory.
Vic and the Strike Team decide to take risky measures to protect themselves from being linked to the Money Train heist. Unfortunately, their plan is interrupted when one of Vic's open cases is suddenly linked to a Narco Corrido song.
Lucas must make a difficult decision regarding Brooke. Haley considers having sex with Nathan.
While the Andromeda is confronted by the Commonwealth fleet and Tri-Jema, Dylan must decide whether or not he can entrust the Route of Ages to them.
When Greg refuses to lend a helping hand in redecorating, Kim hires an interior decorator to design a fireplace for their living room, desperate to prove to Greg that she doesn't need his help.
When Jesse's life hangs in the balance, Brennan must connect to him and lead him through past memories they've shared in order to save his life.
Jake's sullen mood baffles and bothers the family and prompts Alan and Judith to take him to a child psychologist.
Falling in love with a new temporary Montecito employee known only as "Bob the floater" (guest star Christian Kane), Nessa begins pressing her new mystery man for more personal details. However, when she discovers that her new beau is actually suffering from amnesia and walked into the hotel several days again hoping to jar his memory, Nessa turns to Ed in the hopes of uncovering the truth about Bob. Meanwhile, a guest's discovery of a revealing picture of her undressing in a hotel cabana on the internet, sends Danny on the hunt for a peeping camera man whose lens has also captured a revealing side of Delinda. Sam's war of words with a world-champion eater prompts her to enter an eating contest, enlisting Mike as her trainer.
Amy confides to Bright that she may have developed feelings for Ephram and sees him in a new light, but Bright begs her to have mercy on poor Ephram, who is still nursing a broken heart from his recent break-up with Madison. Meanwhile, Linda reveals her HIV status to Delia after the girl confronts her about all the pills she's been taking. While Delia takes the news better than expected, the rest of the town goes ballistic after Linda's secret unintentionally becomes public knowledge. Dr. Abbott faces a potential malpractice suit, and Andy is forced to come clean with Ephram, who doesn't take the news very well.
A police officer collapses and dies after pulling over a car, and the investigation reveals he was murdered. Horatio grows suspicious when Internal Affairs gets involved in the case, leading him to believe that the killing wasn't a random crime. Meanwhile, Calleigh aids an abused woman who is living with one of the suspects in the probe. Yelina begins dating Horatio's nemesis – who is heading up the Internal Affairs inquiry.
When the MacDougals are invited to spend Easter with the Barones, the two families attempt to bond over a 500-piece puzzle. While everyone else gets frustrated with the puzzle, Ray and Pat continue working on it until the wee hours of the night while sharing stories about themselves and their families.
After finding out that Lauren is working for the Covenant, Vaughn is told to keep up the façade of a happy marriage in order to keep tabs on his wife's activities. But he's in for a shock when he uncovers the truth about Lauren's mother, Olivia. Meanwhile, Jack refuses to help exonerate Sloane of his crimes and put in motion a stay of execution, and a monk discloses the identity of the Rambaldi "Passenger" to Sydney.
When Piper is kidnapped and cocooned by the Spider Demon, and becomes Chris infected with the Demon's venom, causing him to mutate into a spider, Paige, Phoebe and Leo try to rescue them. Meanwhile, Leo finally learns why Chris resents him.
Sue meets Jack and Bobby 's mentor who comes to Washington D.C. to ask for help in tracking a suspect whom Wes Kenner believes brought weapons grade uranium into Washington. Jack, Bobby, and Sue must try to track him down before the uranium is used to make a bomb. Dimitrius acts as a relief supervisor for Ted Garrett who is on vacation. Dimitrius gets in trouble for giving the go ahead to take over see case that began in Washington D.C. 's jurisdiction. Larson doesn't like the way Dimitrius is handling the case due to his lack of experience in dealing with the Russians. The team must go to court to make an appeal to have the case kept in Washington D.C. 's jurisdiction. Tara learns that Jack and Bobby's mentor faked his own death. The team must go to court to make an appeal to have the case kept in Washington D.C. 's jurisdiction. Tara learns that Jack and Bobby's mentor faked his own death. Jack soon figures out that was the only way to learn that help was needed.